The Buffalo Bills are set to kick off their season against the Arizona Cardinals this Sunday, facing a mix of challenges and opportunities. The initial injury report for the Week 1 matchup revealed some concerns, but the spotlight remains on Josh Allen and his new-look offense under coordinator Joe Brady.

Buffalo’s injury report listed defensive end Javon Solomon as a non-participant in Wednesday’s practice due to an oblique injury, while backup quarterback Mitchell Trubisky was limited with a knee issue. Safety Cole Bishop, wide receiver Curtis Samuel, and tight end Quintin Morris were all full participants despite minor injuries, giving the Bills a relatively clean slate as they prepare for Arizona.

Meanwhile, the Cardinals also enter with a fairly healthy roster, with only two players listed on their injury report. Wide receiver Xavier Weaver (oblique) did not practice, while tight end Tip Reiman (ankle) was a limited participant. The Cardinals’ injury list, which features two rookie backups, suggests they will field a near-full-strength squad on Sunday. However, the Bills’ focus is less on the Cardinals’ health and more on their own

offensive adjustments. With Stefon Diggs and Gabriel Davis no longer in the lineup, Buffalo will rely on a receiver-by-committee approach featuring Keon Coleman, Curtis Samuel, Marquez Valdes-Scantling, Mack Hollins, and Khalil Shakir. Josh Allen has expressed confidence in this new configuration, emphasizing a team-oriented strategy. “We’ve got a lot of new guys, new faces, and just trying to spread the wealth,” said Allen. “It doesn’t really matter who gets the ball or when they get it”